How Can Mimetics’ Computational Platform be Used to Solve Commercial Problems?
We give you quality control, not just quality assurances.
Many Food & Beverage production systems are driven by biological processes, the prime examples being beer and wine. Brewers have learned over the ages how to monitor the fermentation going on in their tanks by measuring key parameters such as oxygen, sugar and CO2. In more recent times, they have been able to get a picture of the genetics of their yeast. But, up to now, they have not been able to penetrate what is happening in the yeast as the fermentation takes place. This has been a ‘black box’ in the middle of their process. Mimetics’ technology can open up this box, providing enhanced process control for Food & Beverage companies..
Brewers who engage with Mimetics can find ways to use their yeast more efficiently, ensure that each batch accurately reproduces the previous batch and that the effects of changes in products and recipes can be accurately predicted. The same is true for wine makers and other Food & Beverage producers who use yeast or other micro-organisms in the processes.
The AgBio industry is engaged in a continuing quest for increased productivity from the plants and animals that farmers and cultivators raise. From limited and expensive resources of land, water and nutrition, Agriculture around the world is called upon to feed an ever-growing population. Rapid advances in genomics have been useful but reaction to GMO’s has limited their value. AgBio companies also find that there can be enormous hurdles in bringing advances from the lab and greenhouse out into the field and the underlying causes of these problems often remain mysterious. A new generation of AgBio research has begun to focus on microbiomes both outside of and inside of the animal or plant of interest and the result has been enormous data collections that await analysis.
Mimetics computational platform starts from a given genome and works to analyze how those genetic patterns are expressed and the dynamics of the regulatory networks that govern this expression. Two genetically ‘identical’ organisms may respond in very different ways to environmental stresses depending on the circumstances under which those stresses are applied (time of day for example). The same is true for signaling pathways between cells which permit organisms to communicate in a microbiome. These analyses require large amounts of data to be collected according to demanding protocols and then analyzed to extract the dynamics. Mimetics technology is built precisely to handle these challenges.
AgBio also encompasses the commercial use of biological organisms in novel and non-traditional production processes such as bio-fuel manufacture. In this work, the genetics of the organisms have been carefully engineered but there are often practical problems of efficiency which can render the process uncompetitive when measured in purely economic terms. The efficiency is controlled by the response of the organism to the process environment in which it is operating, an environment which is often stressful or even hostile to the organism. A detailed understanding of the dynamics of the regulation of the genes is essential to improving the efficiency of these new and promising processes.
Researchers looking for new drugs are accustomed to identifying ‘targets’ within the molecular pathways that characterize diseased cells. If such targets can be disabled the pathway can be shut down with positive consequences for the health of the cell. Very many new pharmacological interventions have been discovered in just this way. But researchers are often frustrated to find that the disabling of one target can give rise to compensating mechanisms within the cell that permit the pathway to continue to function
Mimetics’ tools can help researchers obtain a more comprehensive picture of the networks that are connected to the targets they are interested in. They can then see how compensating mechanisms or other processes may become unintended consequences of the application of the drug to the target. This can help refine and improve the drug discovery process.
Mimetics is also applying its technology to the problem of identifying new therapies and our research into fungal cell cycles has led us to a new approach to anti-fungal and fungicidal agents. Mimetics continues to do basic research in this area and welcomes opportunities to work with organizations that have drug development expertise and are interested in novel anti-fungal treatments.